General Information

  • ID:  hor006733
  • Uniprot ID:  P37204
  • Protein name:  Glycoprotein hormones alpha chain
  • Gene name:  cga
  • Organism:  Thunnus obesus (Bigeye tuna)
  • Family:  Glycoprotein hormones subunit alpha family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Thunnus (genus), Thunnini (tribe), Scombrinae (subfamily), Scombridae (family), Scombriformes (order), Pelagiaria , Percomorphaceae , Euacanthomorphacea , Acanthomorphata , Ctenosquamata , Eurypterygia , Neoteleostei , Euteleosteomorpha (cohort), Clupeocephala , Osteoglossocephalai , Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0016913 follicle-stimulating hormone activity
  • GO BP:  GO:0007186 G protein-coupled receptor signaling pathway; GO:0010469 regulation of signaling receptor activity; GO:0010893 positive regulation of steroid biosynthetic process
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0016914 follicle-stimulating hormone complex

Sequence Information

  • Sequence:  YPNVDLSNMGCEECTLKKNNVFSRDRPIYQCMGCCFSRAFPTPLKAMKTMTIPKNITSEATCCVAKHSYETEVAGIRVRNHTDCHCSTCYFHKS
  • Length:  94(1-94)
  • Propeptide:  YPNVDLSNMGCEECTLKKNNVFSRDRPIYQCMGCCFSRAFPTPLKAMKTMTIPKNITSEATCCVAKHSYETEVAGIRVRNHTDCHCSTCYFHKS
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  T55 N-linked (GlcNAc...) asparagine;T80 N-linked (GlcNAc...) asparagine
  • Mutagenesis:  NA

Activity

  • Function:  Shared alpha chain of heterodimeric glycoprotein hormones. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. Involved in gametogenesis and steroidogenesis.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  11-34; 14-63; 31-84; 35-86; 62-89
  • Structure ID:  AF-P37204-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P37204-F1.pdbhor006733_AF2.pdbhor006733_ESM.pdb

Physical Information

Mass: 1232430 Formula: C454H715N131O138S14
Absent amino acids: W Common amino acids: CT
pI: 8.26 Basic residues: 16
Polar residues: 39 Hydrophobic residues: 21
Hydrophobicity: -40.64 Boman Index: -18454
Half-Life: 2.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: 2 min Aliphatic Index 49.79
Instability Index: 4162.13 Extinction Coefficient cystines: 6585
Absorbance 280nm: 70.81

Literature

  • PubMed ID:  8138353
  • Title:  Purification and characterization of gonadotropin I and II from pituitary glands of tuna (Thunnus obesus).